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1. Lipides...
2. Exposé
3. No potential conflicts of interest
4. Cardiovascular disease in Switzerland
5. Maladies cardiovasculaires: fardeau humain et économique
6. Cardiovascular diseases in Switzerland
7. Cardiovascular diseases in Switzerland
8. Cardiovascular diseases in Switzerland
9. Facteurs de risque et maladies CV
10. Lipides et maladies CV
11. Causative factors vs bystanders
12. Transport and synthesis of lipids
13. Structure of lipoproteins
14. Structure of lipoproteins
15. The central role of arterial retention of LDL-C in the pathogenesis of atherosclerosis
16. The central role of arterial retention of LDL-C in the pathogenesis of atherosclerosis
17. Lipoprotein(a) causally related to CVD-risk
18. Remnant cholesterol causally related to CVD-risk
19. Exposé
20. Concept change I: Use combination therapy
21. Concept change II: Start Early
22. Concept change II: Start Early
23. Concept change III: Treat (much more) aggressive
24. Exploratory analysis of patients with LDL-C <0.26 mM
25. Exposé
26. LDL-C has both a causal and a cumulative effect on CHD risk
27. Slide 27
28. Genetic-therapy to reduce blood-lipids-levels
29. Comparison of drug technologies for reducing plasma lipids and lipoproteins
30. Lowering PCSK9 with siPCSK9
31. Approaches to reduce LDL-C levels
32. Lowering Lp(a) with apo(a)-antisense
33. Effect of Galnac apo(a) antisense
34. 'Remnant' cholesterol is next on the list
35. 'Remnant' cholesterol is next on the list
36. Opportunities and challenges for the future
37. Gene therapy is next on the list
38. Slide 38
39. Lipid Residual Cardiovascular risk Future Personal Prevention
40. Te future of lipid-lowering strategy to reduce cardiovascular disease
41. Consultation "Lipides" aux HUG
42. Slide 42
Lipides..., Pr F. Mach, 22.05.2018
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