CRP-guided antibiotic durations for Gram-negative bacteremia, 21.07.20

1. C-Reactive Protein–Guided Antibiotic Treatment Duration, 7-Day Treatment, or 14-Day Treatment in Patients With Uncomplicated Gram-Negative Bacteremia
2. Conflit d'intérêt
3. The PIRATE Project
4. “When the drugs don’t work” because we overused them because we lacked evidence showing that less usage is okay
5. Point-of-care-randomization trials
6. Point-of-care-randomization trials
7. A point-of-care RCT to reduce antibiotic use
8. The PIRATE Project : methods
9. The PIRATE Project : the CRP arm
10. The PIRATE Project : results
11. Baseline demographics and clinical characteristics
12. Microbiology
13. Actual durations
14. Primary outcome: clinical failure…
15. Clinical failure by day 30
16. Clinical failure by day 30
17. Clinical failure at 60 and 90 days
18. Risk factors for failure
19. Adverse events
20. Clostridioides difficile infection
21. Emergence of resistance
22. Other outcomes
23. Limitations
24. Conclusions
25. Team PIRATE

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